Cercetare

  1. Titlul proiectului: Deep-Learning and HPC to Boost Biomedical Applications for Health

Acronimul proiectului: DeepHealth

Tip proiect: H2020

Responsabil proiect din partea Sp. Cl. Prof. Dr. Th. Burghele

Valoare contract: 12.800.000 Euro

  1. Titlul proiectului: Epidemiologia genetica a cancerului in Romania.

Acronimul proiectului: RomCan

Tip proiect: International - Programul „Cercetare în Sectoare Prioritare”

Director proiect: Viorel Jinga

Valoare contract: 1.123.000 Euro

  1. Titlul proiectului: Genetic prostate cancer variants as biomarkers of disease progression.

Acronimul proiectului: ProMark

Contract nr. HEALTH-F2-2007-202059/2008, programul european FP7, 2008-2013

Coordonator: deCODE Genetics (Islanda)

Director proiect: dr. Thorunn Rafnar

Rol în proiect: responsabil de proiect din partea UMF “Carol Davila”

Valoare contract: 2 709 577 Euro

  1. Titlul proiectului: Kidney cancer and occupational risk factors in Central and Eastern Europe

Contract nr. ECE/00/06, finanţat de International Agency for Research on Cancer, IARC, Lyon, Franţa şi National Cancer Institute, USA, 2000-2004.

Coordonator: International Agency for Research on Cancer, IARC, Lyon, Franţa

Director proiect: dr. Paul Brennan

Rol în proiect: responsabil proiect pentru UMF Carol Davila

Valoare contract: 19 200 USD

  1. Titlul proiectului: Global Renal Mass Study

Coordonator: Clinical Research Office of the Endourological Society (CROES)

Perioada desfasurare: 2010-2011.

Rol în proiect: responsabil din partea Spitalului „Prof. Dr. Th. Burghele” (partener in proiect)

  1. Titlul proiectului: The Global URS Study

 Coordonator: Clinical Research Office of the Endourological Society (CROES)

Perioada desfasurare: 2010-2011.

Rol în proiect: responsabil din partea Spitalului „Prof. Dr. Th. Burghele” (partener in proiect)

  1. Titlul proiectului: “Workshop cu sesiuni practice în prostatectomia radicală robotică”

Desfăşurat în cadrul Spitalului Clinic “Prof. Dr. Th. Burghele” Bucuresti, 18-19 Noiembrie 2011

Codul CNCSIS al manifestării a fost  PN-II-IDWE-2011-027.

Buget: 30.000 lei

Director proiect

  1. Titlul proiectului: Optimizarea diagnosticului precoce in adenocarcinomul prostatic la pacienti cu sindrom metabolic prin corelarea factorilor genetici, anatomopatologici si biochimici.

Acronimul proiectului :   ADENODIAG

Perioada derularii:  18/09/2007 - 18/09/2010

Valoarea totala a proiectului:  1.995.700 lei

Directorul de proiect:  Conf. Dr. Mischianu Dan Liviu Dorel

Responsabil din partea Clinicii de Urologie “Prof. Dr. Th. Burghele” (partener in proiect)

  1. Titlul proiectului: Markerii moleculari - Baza comuna de screening in tumorile epiteliale maligne

Perioada derularii: 2008 - 2011

Valoarea proiectului: 458.066 lei

Parteneri:

  • Spitalul Clinic “Sf. Ioan”, Bucuresti (SCSI)
  • Spitalul Universitar de Urgenta, Bucuresti (SUUB)
  • Spitalul Clinic “Coltea”, Bucuresti (SCC)
  • Spitalul Clinic “Theodor Burghele”, Bucuresti (SCTB) –
  • Spitalul Clinic de Urgenta Floreasca, Bucuresti (SCUB)
  • Academia Oamenilor de Stiinta din Romania (AOSR)

Director proiect: Dr Valeria Tica

Responsabil din partea Clinicii de Urologie “Prof. Dr. Th. Burghele” (partener in proiect)

  1. Studiu de faza III : "AV-951-09-301, A phase 3, randomized, controlled, multi-center, open label study to compare Tivozanib (AV-951) to Sorafenib in subjects with advanced renal cell carcinoma ", inceput in Ianuarie 2010 si aflat in desfasurare in cadrul Sectiei III Urologie - Spitalul Clinic "Prof. Dr. Th. Burghele".
  2. Studiu de faza III : "AV-951-09-902, An Extension Treatment Protocol for Subjects who have Participated in a Phase 3 Study of Tivozanib Sorafenib in Renal Cell Carcinoma", inceput in martie 2010 si aflat in desfasurare in cadrul Sectiei III Urologie - Spitalul Clinic "Prof. Dr. Th. Burghele".
  3. Studiu de faza II/III: AN International, Randomised, Double Blind, Placebo Controlled, Parallel Group Study to Investigate whether Trovax, Added to First Line Standard of Care Therapy, Prolongs the Survival of Patients WITH Locally Advanced or Metastatic Clear Cell Renal Adenocarcinoma" inceput in Oct. 2006 si incheiat in Apr. 2010, studiu desfasurat in cadrul Sectiei III Urologie-Spitalul Clinic "Prof. Dr.Th. Burghele".
  4. Studiu de faza II/III: "A randomized, open-label, multi-centre, phase II/III study on treatment with ABR-217620 combined with INF-α vs.INF-α alone in patients with advanced renal cell carcinoma", inceput in Febr. 2007 si aflat in desfasurare in cadrul Sectiei III Urologie -Spitalul Clinic "Prof. Dr. Th. Burghele".
  5. Studiu de faza 1b/2: "Study of Docetaxel and Prednisone, with or withour ISIS 183750 (an elF4E Inhibitor), in Patients with Castrate-Resistant Prostate Cancer", inceput in ianuarie 2011 si aflat in desfasurare in cadrul Sectiei III Urologie - Spitalul Clinic "Prof. Dr.Th. Burghele”.
  6. Studiu de faza III: "An open-label, multi-centre, extension study, evaluating the long-term safety and tolerability of study drug one-month dosing regimen in patients with prostate cancer requiring androgen ablation therapy", inceput in Mai 2007 si aflat in desfasurare in desfasurare in cadrul Sectiei III Urologie- Spitalul Clinic "Prof. Dr. Th. Burghele".
  7. Studiu de faza III: "An open-label, multi-centre, randomised, parallel-arm one-year trial, comparing the efficacy and safety of study drug three-month dosing regimen with Goserelin Acetate in patients with prostate cancer requiring androgen deprivation therapy", desfasurat intre August 2009 si Martie 2011 in cadrul Sectiei III Urologie -Spitalul Clinic "Prof. Dr. Th. Burghele".
  8. Studiu de faza III: "An open-label, multi-centre, randomised, parallel-group, dose-finding study, investigating efficacy and safety of two study drug three-month dosing regimens in patients with prostate cancer requiring androgen ablation therapy, desfasurat intre Iunie 2007 si August 2008, in cadrul Sectiei III Urologie -Spitalul Clinic "Prof. Dr. Th. Burghele".
  9. Studiu de faza III, cu protocolul C21004: A Phase 3, Randomized, Double-Blind, Multicenter trial Comparing Orteronel Plus Prednisone with Placebo plus Prednisone in Patents with Chemotherapy - Naive Metastatic Castration-Resistant Prostate Cancer.
  10. Studiu de faza III, cu protocolul C21005: A Phase 3, Randomized, Double-Blind, Multicenter trial Comparing Orteronel Plus Prednisone with Placebo plus Prednisone in Patents with Metastatic Castration-Resistant Prostate Cancer that has Progressed during or following Docetaxel-based therapy.
  11. Studiu de faza II cu protocolul C21012: A Phase 2, Open Label, Single-Arm, Multidose Study to Investigate the Effects of Orteronel on the QT/QTc Interval in Patents With Metastatic Castration- Resistant Prostate Cancer.
  12. Un studiu de faza Ib/II cu protocolul GO27983: A Phase Ib/II Study of GDC-0068 or GDC-0980 with Abiraterone Acetate versus Abiraterone Acetatein Patients with Castration-Resistant Prostate Cancer Previously Treated With Docetaxel-Based Chemotherapy.
  13. Investigator principal in studiul Ferring Pharmaceuticals Inc. Study cu protocolul FE 200486 CS35A: Extension Trial, Evaluating the Long-Term Progression-Free Survival of Degarelix or Goserelin Three-Month Dosing Regimens in Patients with Prostate Cancer Requiring Androgen Deprivation Therapy.
  14. Investigator Principal in studiul AstraZeneca de faza III cu protocolul D4280C00004: A Phase III, Randomized. Multicenter, Double-Blind, Double-Dummy, Parallel-Group, Comparative Study to Determine the Efficacy, Safety, and Torelability of Ceftazidime-Avibactam (CAZ-AVI, formerly CAZ 104) Versus Doripenem Followed by Appropriate Oral Therapy in the Treatment of Complicated Urinary Tract Infections, Including Acute Pyelonephritis, With a Gram-Negative Pathogen in Hospitalized Adults.
  15. Investigator Principal in studiul AstraZeneca de faza III cu protocolul D4280C00006 : An Open-Label, Randomized, Multicenter, Phase III Study of Ceftazidime-Avibactam (CAZ-AVI, formerly CAZ104) and Best Available Therapy for the Treatment of Infections Due to Ceftazidime Resistant Gram-Negative Pathogens.
  16. Investigator Principal in studiul clinic international D-20762-Z003: "Efficacy and safety of repeated doses of cetrorelix pamoate in symptomatic patients with BPH" in 2002-2004 sponsores by Zentaris GmbH.
  17. Investigator Principal in studiul clinic international 8401060: "Propiverine hydrochloride immediate release (IR) and extended release (ER): Comparison of efficacy and torelability in patients with overactive bladder" in 2002-2003 sponsored by Apogepha Arzneimittel GmbH.
  18. Investigator Principal in studiul clinic international 8405010: "Efficacy and tolerability of propiverine hydrochloride extended release (ER) compared to immediate release (IR) in patients with neurogenic detrusor overactivity" in 2005-2006 sponsored by Apogepha Arzneimittel GmbH.
  19. Investigator Principal in studiul clinic international 8406031: "Dose-finding study of propiverine hydrochloride after intravesical administration of 15, 30 or 60 mg t.i.d. in patients with neurogenic detrusor overactivity" in 2006-2007 sponsored by Apogepha Arzneimittel GmbH.
  20. Investigator Principal in studiul clinic international D-20761-Z006: "Efficacy and safety of cetrorelix acetate in patients with AUR due to BPH" in 2002-2003 sponsored by Zentaris GmbH.
  21. Investigator Principal in studiul clinic international AEZS-102-036: "Cetrorelix pamoate (AEZS-102) in patients with symptomatic BPH: a double-blind placebo-controlled efficacy study" in 2008-2010 sponsored by Aeterna Zentaris GmbH.
  22. Investigator principal in studiul clinic international de faza III, KMD 3213 IT-CL 0215 desfasurat in Spitalul “Prof. Dr. Th. Burghele” in perioada 2006-2007.
  23. Investigator principal in studiul clinic international, randomizat, dublu-orb, placebo-controlat ACTION 617-EC-008, desfasurat in Spitalul “Prof. Dr. Th. Burghele” in perioada 2005-2006.
  24. Investigator principal in studiul de faza II cu protocolul 3652-CL-0018: A randomized, double-blind, placebo-controlled, parallel group, adaptive, combined Proof of Concept and dose-finding study to investigate efficacy, safety, pharmacodynamics and pharmacokinetics of ASP 3652 in the treatment of female subjects with bladder pain syndrome/ interstitial cystitis.
  25. Investigator principal in studiul de faza II cu protocolul 9785-CL-0222: A randomized, double-blind, phase II, efficacy and safety study of MDV3100 (ASP9785) vs. bicalutamide in castrate men with metastatic prostate cancer.
  26. Investigator principal in studiul de faza III cu protocolul D4320C00033: A randomized, double-blind study to assess the efficacy and safety of 10 mg ZD4054 in combination with Docetaxel in comparison with Docetaxel in patients with metastatic hormone-resistant prostate cancer.
  27. Investigator principal in studiul de faza III cu protocolul D4320C00015: A randomized, placebo-controlled, double-blind study to assess the efficacy and safety of once-daily orally administered ZD4054 10 mg in non-metastatic hormone –resistant prostate cancer patients.

2019

  • Erdafitinib in Locally Advanced or Metastatic Urothelial Carcinoma. Loriot Y, Necchi A, Park SH, Garcia-Donas J, Huddart R, Burgess E, Fleming M, Rezazadeh A, Mellado B, Varlamov S, Joshi M, Duran I, Tagawa ST, Zakharia Y, Zhong B, Stuyckens K, Santiago-Walker A, De Porre P, O'Hagan A, Avadhani A, Jinga V, Siefker-Radtke AO; BLC2001 Study Group. N Engl J Med. 2019 Jul 25;381(4):338-348. doi: 10.1056/NEJMoa1817323.
  • Sex specific associations in genome wide association analysis of renal cell carcinoma. Laskar RS, Muller DC, Li P, Machiela MJ, Ye Y, Gaborieau V, Foll M, Hofmann JN, Colli L, Sampson JN, Wang Z, Bacq-Daian D, Boland A, Abedi-Ardekani B, Durand G, Le Calvez-Kelm F, Robinot N, Blanche H, Prokhortchouk E, Skryabin KG, Burdett L, Yeager M, Radojevic-Skodric S, Savic S, Foretova L, Holcatova I, Janout V, Mates D, Rascu S, Mukeria A, Zaridze D, Bencko V, Cybulski C, Fabianova E, Jinga V, Lissowska J, Lubinski J, Navratilova M, Rudnai P, Świątkowska B, Benhamou S, Cancel-Tassin G, Cussenot O, Trichopoulou A, Riboli E, Overvad K, Panico S, Ljungberg B, Sitaram RT, Giles GG, Milne RL, Severi G, Bruinsma F, Fletcher T, Koppova K, Larsson SC, Wolk A, Banks RE, Selby PJ, Easton DF, Pharoah P, Andreotti G, Beane Freeman LE, Koutros S, Albanes D, Männistö S, Weinstein S, Clark PE, Edwards TL, Lipworth L, Carol H, Freedman ML, Pomerantz MM, Cho E, Kraft P, Preston MA, Wilson KM, Michael Gaziano J, Sesso HD, Black A, Freedman ND, Huang WY, Anema JG, Kahnoski RJ, Lane BR, Noyes SL, Petillo D, Teh BT, Peters U, White E, Anderson GL, Johnson L, Luo J, Chow WH, Moore LE, Choueiri TK, Wood C, Johansson M, McKay JD, Brown KM, Rothman N, Lathrop MG, Deleuze JF, Wu X, Brennan P, Chanock SJ, Purdue MP, Scelo G. Eur J Hum Genet. 2019 Jun 23. doi: 10.1038/s41431-019-0455-9. (Factor de impact: 3,65). PMID: 31231134
  • Genetic Risk Score for Prostate Cancer in the Romanian Population. RAZVAN DANAU, DUMITRU CRISTINEL BADIU, PAUL IORDACHE, RADU URSU, VIORICA RADOI, STEFAN RASCU, GEORGE DANIEL RADAVOI, CRISTIAN SORIN SIMA, CRISTIAN TOMA, BOGDAN BRATICEVICI, MIHAELA MANDU, TITUS VALENTIN GRIGOREAN, VIOREL JINGA. Rom Biotechnol Lett. 2019; 24(1): 100-107. doi: 10.25083/rbl/24.1/100.107
  • The influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study. Johansson M, Carreras-Torres R, Scelo G, Purdue MP, Mariosa D, Muller DC, Timpson NJ, Haycock PC, Brown KM, Wang Z, Ye Y, Hofmann JN, Foll M, Gaborieau V, Machiela MJ, Colli LM, Li P, Garnier JG, Blanche H, Boland A, Burdette L, Prokhortchouk E, Skryabin KG, Yeager M, Radojevic-Skodric S, Ognjanovic S, Foretova L, Holcatova I, Janout V, Mates D, Mukeriya A, Rascu S, Zaridze D, Bencko V, Cybulski C, Fabianova E, Jinga V, Lissowska J, Lubinski J, Navratilova M, Rudnai P, Benhamou S, Cancel-Tassin G, Cussenot O, Weiderpass E, Ljungberg B, Tumkur Sitaram R, Häggström C, Bruinsma F, Jordan SJ, Severi G, Winship I, Hveem K, Vatten LJ, Fletcher T, Larsson SC, Wolk A, Banks RE, Selby PJ, Easton DF, Andreotti G, Beane Freeman LE, Koutros S, Männistö S, Weinstein S, Clark PE, Edwards TL, Lipworth L, Gapstur SM, Stevens VL, Carol H, Freedman ML, Pomerantz MM, Cho E, Wilson KM, Gaziano JM, Sesso HD, Freedman ND, Parker AS, Eckel-Passow JE, Huang WY, Kahnoski RJ, Lane BR, Noyes SL, Petillo D, Teh BT, Peters U, White E, Anderson GL, Johnson L, Luo J, Buring J, Lee IM, Chow WH, Moore LE, Eisen T, Henrion M, Larkin J, Barman P, Leibovich BC, Choueiri TK, Lathrop GM, Deleuze JF, Gunter M, McKay JD, Wu X, Houlston RS, Chanock SJ, Relton C, Richards JB, Martin RM, Davey Smith G, Brennan P. PLoS Med. 2019 Jan 3;16(1):e1002724. doi: 10.1371/journal.pmed.1002724. eCollection 2019 Jan
  • Apalutamide for Metastatic, Castration-Sensitive Prostate Cancer. Chi KN, Agarwal N, Bjartell A, Chung BH, Pereira de Santana Gomes AJ, Given R, Juárez Soto Á, Merseburger AS, Özgüroğlu M, Uemura H, Ye D, Deprince K, Naini V, Li J, Cheng S, Yu MK, Zhang K, Larsen JS, Jinga V, McCarthy S, Chowdhury S; TITAN Investigators. N Engl J Med. 2019 Jul 4;381(1):13-24. doi: 10.1056/NEJMoa1903307. Epub 2019 May 31
  • OBESITY: A DELICATE ISSUE CHOOSING THE ESWL TREATMENT FOR PATIENTS WITH KIDNEY AND URETERAL STONES? Pricop C, Radavoi GD, Puia D, Vechiu C, Jinga V. Acta Endocrinol (Buchar). 2019 Jan-Mar;-5(1):133-138. doi: 10.4183/aeb.2019.133.
  • Once-Daily Plazomicin for Complicated Urinary Tract Infections. Wagenlehner FME, Cloutier DJ, Komirenko AS, Cebrik DS, Krause KM, Keepers TR, Connolly LE, Miller LG, Friedland I, Jinga V, Dwyer JP; EPIC Study Group. N Engl J Med. 2019 Feb 21;380(8):729-740. doi: 10.1056/NEJMoa1801467
  • Darolutamide in Nonmetastatic, Castration-Resistant Prostate Cancer. Fizazi K, Shore N, Tammela TL, Ulys A, Vjaters E, Polyakov S, Jievaltas M, Luz M, Alekseev B, Kuss I, Kappeler C, Snapir A, Sarapohja T, Jinga V, Smith MR; ARAMIS Investigators. N Engl J Med. 2019 Mar 28;380(13):1235-1246. doi: 10.1056/NEJMoa1815671. Epub 2019 Feb 14

2018

  • Occupational exposure to urinary bladder carcinogens - risk factors, molecular mechanisms and biomarkers. Marina Ruxandra Otelea, Viorel Jinga, Alexandru Stefan Catalin Rascu, Iancu Emil Plesea, Amelia Nicoleta Petrescu, Luminita Elena Mitrache, Mihai Olteanu, Dan Bondari, Agripina Rascu. Rom J Morphol Embryol 2018, 59(4)
  • Phytochemical Profile and Biological Activities of Satureja hortensis L.: A Review of the Last Decade. Fierascu I, Dinu-Pirvu CE, Fierascu RC, Velescu BS, Anuta V, Ortan A, Jinga V. Molecules. 2018 Sep 25;23(10). pii: E2458. doi: 10.3390/molecules23102458. FACTOR IMPACT – 3,09
  • Identification of Lynch syndrome risk variants in the Romanian population. Iordache PD, Mates D, Gunnarsson B, Eggertsson HP, Sulem P, Benonisdottir S, Csiki IE, Rascu S, Radavoi D, Ursu R, Staicu C, Calota V, Voinoiu A, Jinga M, Rosoga G, Danau R, Sima SC, Badescu D, Suciu N, Radoi V, Mates IN, Dobra M, Nicolae C, Kristjansdottir S, Jonasson JG, Manolescu A, Arnadottir G, Jensson B, Jonasdottir A, Sigurdsson A, le Roux L, Johannsdottir H, Rafnar T, Halldorsson BV, Jinga V, Stefansson K. J Cell Mol Med. 2018 Dec;22(12):6068-6076. doi: 10.1111/jcmm.13881. Epub 2018 Oct 16
  • Randomized Phase II Study Evaluating Akt Blockade with Ipatasertib, in Combination with Abiraterone, in Patients with Metastatic Prostate Cancer with and without PTEN Loss. de Bono JS, De Giorgi U, Rodrigues DN, Massard C, Bracarda S, Font A, Arranz Arija JA, Shih KC, Radavoi GD, Xu N, Chan WY, Ma H, Gendreau S, Riisnaes R, Patel PH, Maslyar DJ, Jinga V. Clin Cancer Res. 2018 Jul 23. doi: 10.1158/1078-0432.CCR-18-0981.
  • Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer. Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer. Smith MR, Saad F, Chowdhury S, Oudard S, Hadaschik BA, Graff JN, Olmos D, Mainwaring PN, Lee JY, Uemura H, Lopez-Gitlitz A, Trudel GC, Espina BM, Shu Y, Park YC, Rackoff WR, Yu MK, Jinga V, Small EJ. N Engl J Med. 2018 Apr 12;378(15):1408-1418. doi: 10.1056/NEJMoa1715546. Epub 2018 Feb 8
  • Profile of common prostate cancer risk variants in an unscreened Romanian population. Iordache PD, Mates D, Gunnarsson B, Eggertsson HP, Sulem P, Guðmundsson J, Benónísdóttir S, Csiki IE, Rascu S, Radavoi D, Ursu R, Staicu C, Calota V, Voinoiu A, Jinga M, Rosoga G, Danau R, Sima SC, Badescu D, Suciu N, Radoi V, Manolescu A, Rafnar T, Halldórsson BV, Jinga V, Stefánsson K. J Cell Mol Med. 2018 Mar;22(3):1574-1582. doi: 10.1111/jcmm.13433. Epub 2017 Dec 20.
  • Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma. Machiela MJ, Hofmann JN, Carreras-Torres R, Brown KM, Johansson M, Wang Z, Foll M, Li P, Rothman N, Savage SA, Gaborieau V, McKay JD, Ye Y, Henrion M, Bruinsma F, Jordan S, Severi G, Hveem K, Vatten LJ, Fletcher T, Koppova K, Larsson SC, Wolk A, Banks RE, Selby PJ, Easton DF, Pharoah P, Andreotti G, Freeman LEB, Koutros S, Albanes D, Mannisto S, Weinstein S, Clark PE, Edwards TE, Lipworth L, Gapstur SM, Stevens VL, Carol H, Freedman ML, Pomerantz MM, Cho E, Kraft P, Preston MA, Wilson KM, Gaziano JM, Sesso HS, Black A, Freedman ND, Huang WY, Anema JG, Kahnoski RJ, Lane BR, Noyes SL, Petillo D, Colli LM, Sampson JN, Besse C, Blanche H, Boland A, Burdette L, Prokhortchouk E, Skryabin KG, Yeager M, Mijuskovic M, Ognjanovic M, Foretova L, Holcatova I, Janout V, Mates D, Mukeriya A, Rascu S, Zaridze D, Bencko V, Cybulski C, Fabianova E, Jinga V, Lissowska J, Lubinski J, Navratilova M, Rudnai P, Szeszenia-Dabrowska N, Benhamou S, Cancel-Tassin G, Cussenot O, Bueno-de-Mesquita HB, Canzian F, Duell EJ, Ljungberg B, Sitaram RT, Peters U, White E, Anderson GL, Johnson L, Luo J, Buring J, Lee IM, Chow WH, Moore LE, Wood C, Eisen T, Larkin J, Choueiri TK, Lathrop GM, Teh BT, Deleuze JF, Wu X, Houlston RS, Brennan P, Chanock SJ, Scelo G, Purdue MP. Eur Urol. 2017 Nov;72(5):747-754. doi: 10.1016/j.eururo.2017.07.015. Epub 2017 Aug 7. Erratum in: Eur Urol. 2018 May 28;:. PMID: 28797570

2017

  • Genome-wide association study identifies multiple risk loci for renal cell carcinoma. Scelo G, Purdue MP, Brown KM, Johansson M, Wang Z, Eckel-Passow JE, Ye Y, Hofmann JN, Choi J, Foll M, Gaborieau V, Machiela MJ, Colli LM, Li P, Sampson JN, Abedi-Ardekani B, Besse C, Blanche H, Boland A, Burdette L, Chabrier A, Durand G, Le Calvez-Kelm F, Prokhortchouk E, Robinot N, Skryabin KG, Wozniak MB, Yeager M, Basta-Jovanovic G, Dzamic Z, Foretova L, Holcatova I, Janout V, Mates D, Mukeriya A, Rascu S, Zaridze D, Bencko V, Cybulski C, Fabianova E, Jinga V, Lissowska J, Lubinski J, Navratilova M, Rudnai P, Szeszenia-Dabrowska N, Benhamou S, Cancel-Tassin G, Cussenot O, Baglietto L, Boeing H, Khaw KT, Weiderpass E, Ljungberg B, Sitaram RT, Bruinsma F, Jordan SJ, Severi G, Winship I, Hveem K, Vatten LJ, Fletcher T, Koppova K, Larsson SC, Wolk A, Banks RE, Selby PJ, Easton DF, Pharoah P, Andreotti G, Freeman LEB, Koutros S, Albanes D, Männistö S, Weinstein S, Clark PE, Edwards TL, Lipworth L, Gapstur SM, Stevens VL, Carol H, Freedman ML, Pomerantz MM, Cho E, Kraft P, Preston MA, Wilson KM, Michael Gaziano J, Sesso HD, Black A, Freedman ND, Huang WY, Anema JG, Kahnoski RJ, Lane BR, Noyes SL, Petillo D, Teh BT, Peters U, White E, Anderson GL, Johnson L, Luo J, Buring J, Lee IM, Chow WH, Moore LE, Wood C, Eisen T, Henrion M, Larkin J, Barman P, Leibovich BC, Choueiri TK, Mark Lathrop G, Rothman N, Deleuze JF, McKay JD, Parker AS, Wu X, Houlston RS, Brennan P, Chanock SJ. Nat Commun. 2017 Jun 9;8:15724. doi: 10.1038/ncomms15724
  • Abiraterone plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer. Fizazi K, Tran N, Fein L, Matsubara N, Rodriguez-Antolin A, Alekseev BY, Özgüroğlu M, Ye D, Feyerabend S1, Protheroe A, De Porre P, Kheoh T, Park YC, Todd MB, Chi KN, Korbenfeld E, Metrebian S, Kaen L, Staneloni E, Batagelj E, Tan H, Hovey E, Woo H, Frydenberg M, Chua W, D’Hondt L, Evaraert E, Verschaeve V, Wynendaele W, Schrijvers D, Waltregny D, Whenham N, Demey W, Franke F, Panhoca R, Damião R, Zucca L, Da Rosa V, Reis R, Scalabrini A, Nahas W, Girotto G, Nogueira A, Gomes A, Coradazzi A, Kurteva G, Siemens R, Gingerich J, Fleshner N, Fradet Y, Morgan S, North S, Saad F, Shayegan B, Zalewski P, Pinochet R, Orellana N, Ding Q, Ye Z, Xie L, Du C, Chen Z, Huang Y, Sun Z, Li H, Jin J, Li C, Wan B, Tian Y, Zhou F, Xie K, Yao X, Qiu M, Zou Q, Na Y, Sun Y, Xue B, Ma L, Martinez C, Salazar M, Larios C, Solano S, Pavlik I, Brodak M, Hora M, Büchler T, Borre M, Johansen J, Mejlholm I, Poulsen M, Wittendorf HE, Tammela T, Vaarala M, Theodore C, Staudacher L, Villers A, Laplaige P, Suttman H, Steuber T, Natale S, Jones R, Tran A, Mazhar D, Mills J, Nyirady P, Salamon C, Torzsok F, Feher J, Géczi L, Lakatos A, Keizman D, Sella A, Frank S, Peer A, Rosenbaum E, Berger R, Mermershtain W, Carteni G, Tonini G, De Giorgi U, Facchini G, Berruti A, Bracarda S, Basso U, Galli L, Tortora G, Alietta M, Fukasawa S, Suzuki H, Hasumi H, Tsuchiya T, Uemura H, Kanayama H, Hashine K, Sato F, Matsumoto H, Oya M, Lee JL, Park S, Keam B, Yun H, Kim Y, Kang B, Lee K, Kim C, Saad M, Sundram M, Calvo D, Moreno R, Rodriquez J, Hernandez C, van den Berg H, De La Rosett J, Van Moorse R, Hunting J, Hendriks M, Kueppers F, Gilling P, Beaven A, Holmes M, Jassem J, Oszukowska E, Niezabitowski J, Jaxa-Larecka D, Chwalinski M, Swiniarski P, Silva C, Conceicãoa P, Fraga A, Mauricio J, Rodrigues T, Pinheiro L, Lima E, Palma Dos Reis J, Volovat C, Jinga V, Harza M, Alyasova A, Budnik N, Bychkov Y, Izmaylov A, Khvorosten D, Matveev V, Novsov A, Vladimirov V, Tevs D, Sheveleva L, Bulanov A, Semenov A, Fadeeva N, Kulikov E, Emelyanov S, Karyakin O, Shirinkin V, Shkolnik M, Lykov A, Skopin P, Kopyltsov E, Mincik I, Mir O, Kliment J, Mikurcik E, Gajdos M, Milichovsky I, Malan J, Bahlmann J, Moshokoa E, Madlala T, Coetzee L, Ribal M, Miñana B, Martinez Breijo S, Carballido J, Olmos D, Requena M, Morote J, Damber JE, Haggman M, Nyman C, Ljungberg B, Bjartell A, Ozen H, Beduk Y, Sozen S, Cetinkaya M, Ozyurt M, Tansug Z, Mungan A, Tanidir Y, Toktas M, Hotko E, Stus V, Lyulko O, Vinnyk Y, Shparyk Y, Sakalo V, Bondarenko I, Paramonov V, Khareba G, Hodos V. N Engl J Med 2017;377(4):352-360.
  • Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma. Arseneault M, Monlong J, Vasudev NS, Laskar RS, Safisamghabadi M, Harnden P, Egevad L, Nourbehesht N, Panichnantakul P, Holcatova I, Brisuda A, Janout V, Kollarova H, Foretova L, Navratilova M, Mates D, Jinga V, Zaridze D, Mukeria A, Jandaghi P, Brennan P, Brazma A, Tost J, Scelo G, Banks RE, Lathrop M, Bourque G, Riazalhosseini Y. Sci Rep 2017; ;7:44876. doi: 10.1038/srep44876.

2016

  • Replication study of 34 common SNPs associated with prostate cancer in the Romanian population. Viorel Jinga, Irma Eva Csiki, Andrei Manolescu, Paul Iordache, Ioan Nicolae Mates, Daniel Radavoi, Stefan Rascu, Daniel Badescu, Paula Badea, Dana Mates. Journal of Cellular and Moelcular Medicine 2016, ISSN: 1582-4934, http://onlinelibrary.wiley.com/doi/10.1111/jcmm.12729/epdf
  • A comprehensive analysis of genome-wide association studies to identify prostate cancer susceptibility loci for the Romanian population. Rădăvoi GD, Pricop C, Jinga V, Mateş D, Rădoi VE, Jinga M, Ursu RI, Bratu OG, Mischianu DL, Iordache P. Rom J Morphol Embryol. 2016;57(2):467-75
  • Insertion of an SVA-E retrotransposon into the CASP8 gene is associated with protection against prostate cancer. Stacey SN, Kehr B, Gudmundsson J, Zink F, Jonasdottir A, Gudjonsson SA, Sigurdsson A, Halldorsson BV, Agnarsson BA, Benediktsdottir KR, Aben KK, Vermeulen SH, Cremers RG, Panadero A, Helfand BT, Cooper PR, Donovan JL, Hamdy FC, Jinga V, Okamoto I, Jonasson JG, Tryggvadottir L, Johannsdottir H, Kristinsdottir AM, Masson G, Magnusson OT, Iordache PD, Helgason A, Helgason H, Sulem P, Gudbjartsson DF, Kong A, Jonsson E, Barkardottir RB, Einarsson GV, Rafnar T, Thorsteinsdottir U, Mates IN, Neal DE, Catalona WJ, Mayordomo JI, Kiemeney LA, Thorleifsson G, Stefansson K. Hum Mol Genet. 2016 Mar 1;25(5):1008-18. doi: 10.1093/hmg/ddv622. Epub 2016 Jan 5
  • Aristolochic acid exposure in Romania and implications for renal cell carcinoma. Turesky RJ, Yun BH, Brennan P, Mates D, Jinga V, Harnden P, Banks RE, Blanche H, Bihoreau MT, Chopard P, Letourneau L, Lathrop GM, Scelo G. Br J Cancer. 2016 Jan 12;114(1):76-80. doi:10.1038/bjc.2015.402.

2015

  • Efficacy of triptorelin pamoate 11.25 mg administered subcutaneously for achieving medical castration levels of testosterone in patients with locally advanced or metastatic prostate cancer. Lebret T, Rouanne M, Hublarov O, Jinga V, Petkova L, Kotsev R, Sinescu I, Dutailly P. Therapeutic Advances in Urology 2015. ISSN: 1756-2872
  • Orteronel plus prednisone in patients with chemotherapy-naive metastatic castration-resistant prostate cancer (ELM-PC 4): a double-blind, multicentre, phase 3, randomised, placebo-controlled trial. Saad F, Fizazi K, Jinga V, Efstathiou E, Fong PC, Hart LL, Jones R, McDermott R, Wirth M, Suzuki K, MacLean DB, Wang L, Akaza H, Nelson J, Scher HI, Dreicer R, Webb IJ, de Wit R; ELM-PC 4 investigator. The Lancet Oncology 2015. ISSN: 1470-2045

2014

  • Variation in genomic landscape of clear cell renal cell carcinoma across Europe. Scelo G, Riazalhosseini Y, Greger L, Letourneau L, Gonzàlez-Porta M, Wozniak MB, Bourgey M, Harnden P, Egevad L, Jackson SM, Karimzadeh M, Arseneault M, Lepage P, How-Kit A, Daunay A, Renault V, Blanché H, Tubacher E, Sehmoun J, Viksna J, Celms E, Opmanis M, Zarins A, Vasudev NS, Seywright M, Abedi-Ardekani B, Carreira C, Selby PJ, Cartledge JJ, Byrnes G, Zavadil J, Su J, Holcatova I, Brisuda A, Zaridze D, Moukeria A, Foretova L, Navratilova M, Mates D, Jinga V, Artemov A, Nedoluzhko A, Mazur A, Rastorguev S, Boulygina E, Heath S, Gut M, Bihoreau MT, Lechner D, Foglio M, Gut IG, Skryabin K, Prokhortchouk E, Cambon-Thomsen A, Rung J, Bourque G, Brennan P, Tost J, Banks RE, Brazma A, Lathrop GM. Nat Commun. 2014 Oct 29;5:5135. doi: 10.1038/ncomms6135 ISSN: 2041-1723
  • Differences in Ureteroscopic Stone Treatment and Outcomes for Distal, Mid-, Proximal, or Multiple Ureteral Locations: The Clinical Research Office of the Endourological Society Ureteroscopy Global Study. Perez Castro E, Osther PJ, Jinga V, Razvi H, Stravodimos KG, Parikh K, Kural AR, de la Rosette JJ; on behalf of the CROES Ureteroscopy Global Study Group. Eur Urol. 2014 Jan 23. pii: S0302-2838(14)00023-2. ISSN: 0302-2838

2013

  • Transarterial embolization of renal vascular lesions after percutaneous nephrolithotomy. Jinga V, Dorobat B, Youssef S, Radavoi G, Braticevici B, Filipoiu F, Balgradean M. Chirurgia (Bucur). 2013 Jul-Aug;108(4):521-9.ISSN: 1221-9118
  • Gentamicin, infections, and acute tubular necrosis in children. M. Bălgrădean, E. Cinteză, F. Filipoiu, Jinga. Farmacia 2013;61:772-80.ISSN: 0014-8237
  • Sudden death of a premature newborn with hypoplastic left heart syndrome. Morfological study of the heart. Filipoiu F.M., Bălgrădean M., Jinga V. Romanian Journal of Legal Medicine 2013; 21:27-30. ISSN: 1221-8618
  • Anatomical description of the deep venous channel from the anterior vestibular wall of the right atrium. Filipoiu F.M., Balgradean M., Brezean I., Jinga V. Rom J Morphol Embryol. 2013;54(3). ISSN: 1220-0522
  • Risk factors and complications leading to mortality from hemolytic uremic syndrome in child. Three case reports. Balgradean M., Cinteza E., Filipoiu F., Jinga V. RJLM 2013; XXI. ISSN: 1221-8618
  • Ventral buccal mucosa graft urethroplasty for penile urethral strictures: a predictable failure? Jinga V, Hurduc M, Voinescu V, Filipoiu F, Balgradeanu M. Chirurgia (Bucur). 2013 Mar-Apr;108(2):245-9. ISSN: 1221-9118
  • Efficacy and tolerability of propiverine hydrochloride extended-release compared with immediate-release in patients with neurogenic detrusor overactivity. Stöhrer M, Mürtz G, Kramer G, Warnack W, Primus G, Jinga V, Manu-Marin A, Calomfirescu N, Strugala G. Spinal Cord. 2013 May;51(5):419-23. doi: 10.1038/sc.2012.174. Epub 2013 Jan 22. ISSN: 1362-4393
  • Death caused by hemolytic-uremic syndrome. Case Balgradean  M., Ceausu M., Cinteza E., Filipoiu F., Hostiuc S., Jinga V., Sirbu D., Spataru R.I. RJLM 2013; XXI

2012

  • A rare case of digestive hemorrhage in an elderly patient: diagnosis and treatment difficulties. Jinga M, Jurcuţ C, Vasilescu F, Becheanu G, Stancu SH, Ciobaca L, Mircescu G, Jinga V. Rom J Morphol Embryol. 2012;53(3 Suppl):831-4. ISSN: 1220-0522
  • Penile abscess and urethrocutaneous fistula following intracavernous injection: a case report. Jinga V, Iconaru V. J Sex Med. 2012 Dec;9(12):3270-3. doi: 10.1111/j.1743-6109.2012.02959.x. Epub 2012 Oct 22. ISSN: 1743-6095
  • Single nucleotide polymorphisms in colorectal cancer: associations with tumor site and TNM stage. Mates IN, Jinga V, Csiki IE, Mates D, Dinu D, Constantin A, Jinga M. J Gastrointestin Liver Dis. 2012 Mar;21(1):45-52. ISSN: 1841-8724
  • A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer. Gudmundsson J, Sulem P, Gudbjartsson DF, Masson G, Agnarsson BA, Benediktsdottir KR, Sigurdsson A, Magnusson OT, Gudjonsson SA, Magnusdottir DN, Johannsdottir H, Helgadottir HT, Stacey SN, Jonasdottir A, Olafsdottir SB, Thorleifsson G, Jonasson JG, Tryggvadottir L, Navarrete S, Fuertes F, Helfand BT, Hu Q, Csiki IE, Mates IN, Jinga V, Aben KK, van Oort IM, Vermeulen SH, Donovan JL, Hamdy FC, Ng CF, Chiu PK, Lau KM, Ng MC, Gulcher JR, Kong A, Catalona WJ, Mayordomo JI, Einarsson GV, Barkardottir RB, Jonsson E, Mates D, Neal DE, Kiemeney LA, Thorsteinsdottir U, Rafnar T, Stefansson K. Nat Genet. 2012 Dec;44(12):1326-9. doi: 10.1038/ng.2437. Epub 2012 Oct 28. ISSN: 1061-4036
  • A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23. Wu X, Scelo G, Purdue MP, Rothman N, Johansson M, Ye Y, Wang Z, Zelenika D, Moore LE, Wood CG, Prokhortchouk E, Gaborieau V, Jacobs KB, Chow WH, Toro JR, Zaridze D, Lin J, Lubinski J, Trubicka J, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Jinga V, Bencko V, Slamova A, Holcatova I, Navratilova M, Janout V, Boffetta P, Colt JS, Davis FG, Schwartz KL, Banks RE, Selby PJ, Harnden P, Berg CD, Hsing AW, Grubb RL 3rd, Boeing H, Vineis P, Clavel-Chapelon F, Palli D, Tumino R, Krogh V, Panico S, Duell EJ, Quirós JR, Sanchez MJ, Navarro C, Ardanaz E, Dorronsoro M, Khaw KT, Allen NE, Bueno-de-Mesquita HB, Peeters PH, Trichopoulos D, Linseisen J, Ljungberg B, Overvad K, Tjønneland A, Romieu I, Riboli E, Stevens VL, Thun MJ, Diver WR, Gapstur SM, Pharoah PD, Easton DF, Albanes D, Virtamo J, Vatten L, Hveem K, Fletcher T, Koppova K, Cussenot O, Cancel-Tassin G, Benhamou S, Hildebrandt MA, Pu X, Foglio M, Lechner D, Hutchinson A, Yeager M, Fraumeni JF Jr, Lathrop M, Skryabin KG, McKay JD, Gu J, Brennan P, Chanock SJ. Hum Mol Genet. 2012 Jan 15;21(2):456-62. doi: 10.1093/hmg/ddr479. Epub 2011 Oct 18. ISSN: 0964-6906

2011

  • A germline variant in the TP53 polyadenylation signal confers cancer susceptibility. Stacey SN, Sulem P, Jonasdottir A, Masson G, Gudmundsson J, Gudbjartsson DF, Magnusson OT, Gudjonsson SA, Sigurgeirsson B, Thorisdottir K, Ragnarsson R, Benediktsdottir KR, Nexø BA, Tjønneland A, Overvad K, Rudnai P, Gurzau E, Koppova K, Hemminki K, Corredera C, Fuentelsaz V, Grasa P, Navarrete S, Fuertes F, García-Prats MD, Sanambrosio E, Panadero A, Juan AD, Garcia A, Rivera F, Planelles D, Soriano V, Requena C, Aben KK, Rossum MM, Cremers RG, Oort IM, van Spronsen DJ, Schalken JA, Peters WH, Helfand BT, Donovan JL, Hamdy FC, Badescu D, Codreanu O, Jinga M, Csiki IE, Constantinescu V, Badea P, Mates IN, Dinu DE, Constantin A, Mates D, Kristjansdottir S, Agnarsson BA, Jonsson E, Barkardottir RB, Einarsson GV, Sigurdsson F, Moller PH, Stefansson T, Valdimarsson T, Johannsson OT, Sigurdsson H, Jonsson T, Jonasson JG, Tryggvadottir L, Rice T, Hansen HM, Xiao Y, Lachance DH, O Neill BP, Kosel ML, Decker PA, Thorleifsson G, Johannsdottir H, Helgadottir HT, Sigurdsson A, Steinthorsdottir V, Lindblom A; Swedish Low-risk Colorectal Cancer Study Group, Sandler RS, Keku TO, Banasik K, Jørgensen T, Witte DR, Hansen T, Pedersen O, Jinga V, Neal DE, Catalona WJ, Wrensch M, Wiencke J, Jenkins RB, Nagore E, Vogel U, Kiemeney LA, Kumar R, Mayordomo JI, Olafsson JH, Kong A, Thorsteinsdottir U, Rafnar T, Stefansson K. Nat Genet. 2011 Sep 25;43(11):1098-103. doi: 10.1038/ng.926. ISSN: 1061-4036
  • Variant of TREM2 associated with the risk of Alzheimer's disease. T Jonsson, H Stefansson, S Steinberg, et al. – N Engl J Med 2013;368:107-116.
  • Correlation between albuminemia, natremia and survival rates in patients with hepatorenal syndrome. Niculae A, Jinga M, Ciocâlteu A, Lascăr I, Jinga V, Checheriţă IA. Rom J Morphol Embryol. 2011;52(3):863-6. ISSN: 1220-0522
  • Occupational exposure to arsenic, cadmium, chromium, lead and nickel, and renal cell carcinoma: a case-control study from Central and Eastern Europe. Boffetta P, Fontana L, Stewart P, Zaridze D, Szeszenia-Dabrowska N, Janout V, Bencko V, Foretova L, Jinga V, Matveev V, Kollarova H, Ferro G, Chow WH, Rothman N, van Bemmel D, Karami S, Brennan P, Moore LE. Occup Environ Med. 2011 Oct;68(10):723-8. ISSN: 1351-0711
  • Silodosin therapy for lower urinary tract symptoms in men with suspected benign prostatic hyperplasia: results of an international, randomized, double-blind, placebo- and active-controlled clinical trial performed in Europe. Chapple CR, Montorsi F, Tammela TL, Wirth M, Koldewijn E, Jinga V, Fernández Fernández E; European Silodosin Study Group. Eur Urol. 2011 Mar;59(3):342-52.
  • Screening for Prostatic Tumors in Metabolic Syndrome Patients in Romania. Rusu F, Rusu E, Radulian G, Enache G, Jinga M, Rusu A, Jinga V, Codreanu O, Mischianu D, Cheta D. Acta Endo (Buc) 2011 (7): 47-58.

2010

  • Genetic correction of PSA values using sequence variants associated with PSA levels. Gudmundsson J, Besenbacher S, Sulem P, Gudbjartsson DF, Olafsson I, Arinbjarnarson S, Agnarsson BA, Benediktsdottir KR, Isaksson HJ, Kostic JP, Gudjonsson SA, Stacey SN, Gylfason A, Sigurdsson A, Holm H, Bjornsdottir US, Eyjolfsson GI, Navarrete S, Fuertes F, Garcia-Prats MD, Polo E, Checherita IA, Jinga M, Badea P, Aben KK, Schalken JA, van Oort IM, Sweep FC, Helfand BT, Davis M, Donovan JL, Hamdy FC, Kristjansson K, Gulcher JR, Masson G, Kong A, Catalona WJ, Mayordomo JI, Geirsson G, Einarsson GV, Barkardottir RB, Jonsson E, Jinga V, Mates D, Kiemeney LA, Neal DE, Thorsteinsdottir U, Rafnar T, Stefansson K. Sci Transl Med. 2010 Dec 15;2(62):62ra92. doi: 10.1126/scitranslmed.3001513.
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